|COLLECTION AND CONSUMPTION OF SELF ADMINISTERED
ANTI-TUBERCULOSIS DRUGS UNDER PROGRAMME CONDITION
|GD Gothi, D Savic, GVJ Baily, K Padmanabha Rao, SS
Nair & GE Rupert Samuel: Indian J TB 1971, 18, 107-13.
This investigation was to find out the drug consumption
among tuberculosis patients put on domiciliary self administered
chemotherapy, in terms of proportion of patients that make various
levels of drug collections and proportion among them that consume
drugs at different points of time during the course of treatment.
In all, 816 tuberculosis patients aged 5 years and above residing
in Bangalore city were admitted to the study. They were randomly
divided into 6 groups at the time of inclusion into the study, for
examination of urine samples for the presence of INH and PAS. One
surprise urine sample was collected from each patient at the pre
determined time after the drug collection. The samples of urine
were collected from one group at first month, another at second
month, third at fourth month, fourth at sixth month, fifth at ninth
month and sixth at twelfth month of treatment. Urine samples were
collected within 33 days of drug collection for the month because
the drugs were supplied at a time for the said period. Urine specimens
were examined for the presence of drugs or their metabolites. For
INH, NM test & acetyl INH test and for PAS, ferriechloride and
case test were performed. The drug collection was judged on the
basis of treatment record and its consumption on the basis of results
of urine examination.
Of the total patients included in the study, 54%
made 10 or more drug collections over a period of 15 months. The
initial radiological or bacteriological status or severity of disease
did not influence the drug collection; however smaller proportion
of old persons in both sexes collected the drugs for 10 months or
more. Urine specimens of 71% of patients who had collected drugs
were positive for INH on any one day. Bacteriological quiescence
was obtained among the 82% INH sensitive patients who had made 10
or more collections. The above findings suggest that the patients
who collect drugs also consume with fair amount of regularity and
achieve a high degree of bacteriological quiescence.
|KEY WORDS: SELF ADMINISTERED REGIMEN, DRUG COLLECTION
LEVEL, DRUG CONSUMPTION, CONTROL PROGRAMME, COMPLIANCE.