|ALLERGY PRODUCING CAPACITY OF MADRAS AND DANISH
BCG VACCINES AS SEEN AMONG SCHOOL CHILDREN IN BANGALORE
|Raj Narain, Kul Bhushan & M Subramanian: Indian
J TB 1961, 7, 1-15.
In all, 1,259 students aged 11-19 years from three
boys high school of Bangalore, formed the study group. They were
tuberculin tested with 1 TU RT 23 containing Tween 80. Boys with
a reaction of 13 mm or less to tuberculin test and willing for BCG
vaccination were allocated in 3 groups: (i) to be vaccinated with
Madras vaccine (211), (ii) to be vaccinated with Danish
Vaccine (236), (iii) control with saline injection (231)
(placebo). Strength of Madras and Danish vaccines used was same,
0.075 mg per dose. After 3 months of vaccination, second tuberculin
test with 1 TU RT 23 with Tween 80 was given to 575 boys included
in both the vaccinated groups and in the control group. A follow
up at one year after vaccination was done among 328 boys, who
were again tuberculin tested.
The analysis of data shows that the mean size of
post-vaccination tuberculin test induration among Madras BCG vaccinated
group was 11.8 mm and among Danish BCG vaccinated group, it was
11.9 mm, the standard deviation were 3.8 and 4.5 mm respectively.
The above differences between the 2 vaccinated groups were not-statistically
significant. Similarly, the post-vaccination allergy in the two
BCG vaccinated groups at the end of one year was not-significantly
different. The mean size of the scar produced by two vaccines were
also smaller. The post-vaccination allergy among persons whose pre-vaccination tuberculin induration was 9 mm or more to 1 TU RT 23
with Tween 80, did not increase by more than 4 mm after vaccination.
While the group whose pre-vaccination tuberculin induration was
below 9 mm, had an increase of post-vaccination allergy of a little
over 8 mm. It is concluded that the allergy producing capacity
of the Danish and Madras vaccines was not different.
|KEY WORDS: BCG VACCINE, POST-VACCINATION ALLERGY,
MADRAS VACCINE, DANISH VACCINE.