|SIMULTANEOUS SMALLPOX AND BCG VACCINATION
|Kul Bhushan, GVJ Baily & VB Naidu: Indian J
TB 1968, 15, 52-56.
A study was carried out in Bangalore city corporation
area with the following objectives; when BCG vaccination is administered
simultaneously with primary smallpox vaccination to infants; (i)
whether any immunological interferences take place as indicated
by the development of vaccination lesion and post-vaccination allergy
due to BCG vaccination and the development of the local lesion (take
rate) of smallpox vaccination; (ii) whether the incidence of complications
are higher among those simultaneously vaccinated and, (iii) whether
the population will accept a procedure involving two vaccinations.
BCG technicians and the smallpox vaccinators registered all the
eligible children after house to house visit and randomly allocated
to three groups. A total of 789 children aged below one year were
admitted to the study. While 315 were vaccinated simultaneously
with BCG and smallpox vaccines (BCG on the right arm and smallpox
on the left), 255 were vaccinated with smallpox vaccine only and
219 with BCG vaccine. All 789 children were followed up on the 5th,
21st, 90th and 93rd day of vaccination. The 5th and 21st day followups
were to study the development and healing of smallpox vaccination
lesions, whereas the 21st, 90th and 93rd day followups were for
BCG vaccination lesions. The 90th and 93rd followups were for tuberculin
testing and reading.
It was found that there was no evidence of immunological
interference between the two vaccines when administered simultaneously
i.e., the development of lesion of smallpox vaccination among the
simultaneously vaccinated group was similar to the development of
the smallpox vaccination lesion among the only smallpox vaccinated
group and, the post-vaccination allergy due to BCG among the simultaneously
vaccinated group was similar to the post-vaccination allergy
among the only BCG vaccinated group. The complications due to vaccinations
were very few and similar among the simultaneously vaccinated as
compared to the other respective groups. The acceptability of simultaneous
vaccination was higher than BCG alone. The above study has demonstrated
that BCG and smallpox vaccinations can be administered simultaneously.
|KEY WORDS: SIMULTANEOUS BCG & SMALLPOX VACCINATION,
ASSESSMENT, ACCEPTABILITY, COMMUNITY.