|A COMPARATIVE STUDY OF PREVALENCE OF DRUG RESISTANCE
TO MAJOR ANTI TUBERCULOSIS DRUGS
|K Padmanabha Rao: Proceed Natl TB & Chest Dis
Workers Conf, Hyderabad, 1967, 52-62.
A comparative study to find out the prevalence
of resistance to the major anti-TB drugs, SM, INH and PAS, under
different situations was carried out. The situations considered
were: (i) Sanatoria, (ii) Urban tuberculosis clinic, (iii) Rural
general health dispensaries, (iv) the mass Case-finding among selected
group of population and (v) survey of general population.
The prevalence of drug resistance to INH was 53%,
the highest among sanatoria patients and 11%, the lowest among
patients discovered in tuberculosis surveys i.e., situation
(v). Among newly diagnosed culture positive tuberculosis patients
of urban tuberculosis clinic, rural general health institutions
and selected Case-finding programmes, i.e., situations (ii), (iii)
and (iv), proportion of patients with INH resistant organisms were
26%, 33% and 16% respectively. The resistance rates were the highest
in age group 25 to 44 in all 5 situations, case-wise rates were
not significantly different. The prevalence of INH and streptomycin
resistance among patients found in special mass Case-finding tuberculosis
programme, were significantly lower than among patients attending
special tuberculosis services or general health institutions.
The findings of this study show that prevalence
of drug resistance among patients attending tuberculosis services
and general health institutions is not a true index of the prevalence
of drug resistance in the community and it varies under different
|KEY WORDS: DRUG RESISTANCE, INH, STREPTOMYCIN,
PAS, GENERAL POPULATION, CLINIC, SANATORIA, PHIs.