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006 |
SOME ASPECTS OF A TB PREVALENCE SURVEY IN A SOUTH
INDIAN DISTRICT |
Raj Narain, A Geser, MV Jambunathan & M Subramanian:
Bull WHO 1963, 29, 641-64 & Indian J TB 1963, 9, 85-116. |
The objective was to establish the prevalence rates
for tuberculosis infection, radiologically active pulmonary tuberculosis
and bacteriologically confirmed diseases for different age and sex
groups. Tumkur District in Mysore State consisting of 2,392 villages,
10 towns of was selected for the study. The district headquarter
town Tumkur was excluded from the survey. Random sample of 62 villages
and 4 town blocks having a population of 34,746 persons constituted
the study population. All the individuals available in the registered
population were given a Mantoux test with 1 TU RT 23 with Tween
80. Longitudinal diameter of induration was read 3-4 days after
the test. At the time of tuberculin test, all persons aged 10 years
and above were offered a single 70mm photofluorogram. For each picture
read as abnormal, a spot specimen of sputum of the individual concerned
was collected at the time of reading the tuberculin test. Age and
sex distribution of infection and disease were studied.
Various parameters concerning the prevalence of
infection and disease in the community were reported. Prevalence
rate of infection in all ages and both sexes of the population was
found to be 38.3%, radiologically active tuberculosis 1.86% and
0.41% sputum positive disease. The infection and disease increased
with age; of the total diseased, half were in age group 40 years
and more and about 2/3 among males.
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KEY WORDS: SURVEY, PREVALENCE, INFECTION, DISEASE,
CASE, COMMIUNITY, RURAL, URBAN. |
010 |
DISTRIBUTION OF INFECTION AND DISEASE AMONG HOUSEHOLDS
IN A RURAL COMMUNITY |
Raj Narain, SS Nair, G Ramanatha Rao & P Chandrasekhar:
Bull WHO 1966, 34, 639-54 & Indian J TB 1966, 13, 129-46. |
Studies on the distribution of tuberculous infection
and disease in households have mostly been restricted to the examination
of contacts of known cases. Clinical experience has lead to a strong
belief that tuberculosis is a family disease and contact examination
is a must for case-finding programmes. A representative
picture of the distribution of infection and disease in households
can be obtained only from a tuberculosis prevalence survey.
This paper reports an investigation, based on a
prevalence survey in a rural community in south India. The survey
techniques and study population have been described in an earlier
report. Briefly, the defacto population was given a tuberculin test
with 1 TU of PPD RT 23 with Tween 80 and those aged 10 years and
above were examined by 70mm photofluorography. All the X-ray pictures
were read by two independent readers. Those with any abnormal shadows
by either of the two readers were eligible for examination of a
single spot specimen of sputum by direct smear and culture. The
defacto population numbered 29,813 and tuberculin test results were
available for 27,115. After excluding BCG scars, the study population
of 24,474 was distributed over 5,266 households which were further
classified as bacillary case household with atleast
one bacteriologically confirmed case, X-ray case household
with atleast one radiologically active case but with no bacillary
cases and non-case household with neither a bacillary
nor an X-ray case. Total bacillary cases were 77 and were distributed
in 75 household. 74 households had one case each and one household
had 3 bacillary cases.
The findings of the study have thrown considerable
doubt on the usefulness of contact examination in tuberculosis control;
(1) over 80% of the total number of infected persons, in any age
group, occurred in households without cases, (2) cases of tuberculosis
occurred mostly singly in households, and the chance of finding
an additional case by contact examination in the same household
is extremely small, (3) a common belief has been that prevalence
of infection in children in 0-4 age group is a good index of disease
in households, but in this study about 32% of households with cases
of tuberculosis had no children in this age group, (4) in houses
with bacteriologically confirmed case only 12% of the children in
0-4 age group showed evidence of infection, a possible explanation
of such a low intensity of infection could be that there is resistance
to infection. It is well known that some children even after repeated
BCG vaccination do not become tuberculin positive. It is felt that
a large number of children do inhale tubercle bacilli, but a primary
complex does not develop or even if it develops, the children remain
tuberculin negative. A hypothesis has been made that in addition
to resistance to infection, there is something known as resistance
to disease. Otherwise, it is difficult to explain why under
conditions of heavy exposure in infection, only some individuals
develop evidence of infection and very few develop disease thereafter.
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KEY WORDS: PREVALENCE, INFECTION, DISEASE,
CONTACT EXAMINATION, HOUSEHOLD, RURAL COMMUNITY. |
013 |
PROBLEMS IN DEFINING A CASE OF PULMONARY
TUBERCULOSIS IN PREVALENCE SURVEYS |
Raj Narain, SS Nair, K Naganna, P Chandrasekhar, G
Ramanatha Rao & Pyare Lal: Bull WHO 1968, 39, 701-29. |
Generally there is no acceptable definition of
the term case of pulmonary tuberculosis, although such
a definition is of fundamental importance both in clinical medicine
where results of various chemotherapeutic regimens are compared,
as well as for the comparison of different epidemiological data.
The main purpose of this paper is to focus attention on the difficulties
of defining a case on the basis of bacteriological examination,
X-ray examination and tuberculin test. Data from two successive
prevalence surveys in a random sample of 134 villages in Bangalore
district with a population 70,000 have been utilized to illustrate
some of the difficulties in defining a case of pulmonary
tuberculosis for reporting the prevalence or incidence of the diseases.
The entire population was tuberculin tested with 1 TU RT 23 with
Tween 80 at both rounds and those 5 years of age and older were
examined by 70mm photofluorogram. The sputum specimens (spot and
overnight) were collected from those with any abnormality on X-ray
as recorded by either of the two independent readers. Both the specimens
were examined by fluorescent microscopy and Ziehl-Neelsen technique
and by culture.
Analysis of data has shown that the term a
case of pulmonary tuberculosis does not represent a single
uniform entity, but embraces cases of several types, differing considerably
in their tuberculin sensitivity, results of X-ray and sputum examination,
in the reliability of their diagnosis and mortality experience.
The status of cases found at initial and subsequent surveys showed
changes with time, and such changes show considerable differences
for the various types of cases. It was felt that a single straight-forward
definition of a case was not possible to suit all situations. One
has to use more than one definition. Although theoretically, finding
a single bacillus in sputum should be adequate proof of pulmonary
tuberculosis, it was shown that finding of a few bacilli (3 or less)
was very often due to artifacts and should not be the basis for
a diagnosis. It has also been found that positive radiological findings,
in the absence of bacteriological confirmation, indicate only a
high risk of the disease and not necessarily pulmonary tuberculosis.
Direct microscopy appears to be a consistent index of disease but
in community surveys has the limitation of missing a substantial
proportion of cases and of adding some false ones.
In view of the difficulty of providing a single
definition of a case of tuberculosis, four indices have been suggested.
(1) Cases definitely positive by direct smear; (2) Cases definitely
positive by culture; (3) All cases positive by culture (including
less than twenty colonies); (4) Sputum positive cases which are
radiologically active. Each of these could be used for different
situations. However, it was concluded that, there seems to be no
option but to use more than one definition for assessing the prevalence
and incidence of disease.
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KEY WORDS: CASE-DEFINITION, SURVEY, PREVALENCE,
DISEASE. |
016 |
SOME EPIDEMIOLOGICAL ASPECTS OF TUBERCULOUS DISEASE
AND INFECTION IN PAEDIATRIC AGE GROUP IN A RURAL COMMUNITY |
GD Gothi, SS Nair & Pyare Lal: Indian Paediatrics
1971, 8, 186-94. |
The prevalence and incidence rates of tuberculous
infection and disease in the community are known in the age group
10 years and above from several surveys carried out so far. The
present paper provides various parameters of tuberculosis in particular
in the pediatric age group. A random sample of 119 villages in 3
taluks of Bangalore district were surveyed 4 times from May 1961
to July 1968 at intervals of 18 months, 3 years and 5 years of the
initial survey. Tuberculin test was done for the entire available
population with 1 TU PPD RT 23 with Tween 80, and 70mm X-ray for
all available persons aged 5 years and above. Two samples of sputum
were obtained from the X-ray abnormals, and examined by smear and
culture.
It was found that prevalence of infection increased
with age from 2.1% at 0-4 year age group to 16.5% at 10-14 year
age group, compared to 47% at 15 years and above age group. Prevalence
of disease in 5-14 year age group was considerably lower than in
age group 15 years or more. Tuberculosis morbidity increased with
the size of tuberculin reaction and it was high among children with
reaction 20mm or more. Incidence of infection increased with age
from 0.9% per year in age group 0-4 years to 2.8% per year among
that of 15 years and above. Incidence of disease also showed the
same phenomenon-, rising from 0.5% in age group 5-9 to 4% per year
in the age group 15 years and above. There were 10 sputum positive
cases in 5-14 years of age in first survey, of them, 8 became negative
and one died. While from among 152 cases in 15 years and above age
group, 48 became negative, 72 died and 32 remained positive. The
fate of cases of pulmonary tuberculosis in 5-14 years age was not
as serious as in 15 years and above age group. The survey had no
means of examining miliary and meningeal tuberculosis.
Children as well as adults with larger reaction
of 20mm or more to tuberculin test had higher mortality. This could
be considered due to tuberculous infection after taking into account
death due to non- tuberculous reasons in both the infected and uninfected
groups. Use of chemoprophylaxis might be considered for those who
give history of contact with open cases and have tuberculin reaction
size 20mm or more.
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KEYWORDS: CHILDREN, RURAL COMMUNITY, PREVALANCE,
INCIDENCE, INFECTION, DISEASE, TUBERCULIN, INDURATION SIZE, MORTALITY,
CHEMOPROPHYLAXIS. |
017 |
DISTRIBUTION OF TUBERCULOUS INFECTION AND DISEASE
IN CLUSTERS OF RURAL HOUSEHOLDS |
SS Nair, G Ramanatha Rao & P Chandrasekhar: Indian
J TB 1971, 18, 3-9. |
Data from 62 randomly selected villages in a district
of south India, which formed part of a prevalence survey carried
out by the National Tuberculosis Institute, Bangalore, during 1960-61,
has been made use of. The survey covered 29,813 persons in 5,266
households. There were 70 cases with bacilli demonstrable either
in smear or culture and 300 suspect cases. Using the village map
(prepared by survey staff), case clusters were formed
first, with each case household as nucleus and adjacent households
within a maximum distance of about 20 meters on either side of the
case households. Households closest to the nucleus household on
either side have been called as 1st neighbourhood and those coming
next in proximity on either side as a 2nd neighbourhood and so on.
The case household and its four neighbourhood together was called
a cluster. If another case household was found within 4th neighbourhood
of the first case the cluster was extended by including the 4th
neighbourhood of the new case also. Such clusters were called composite
case clusters and clusters with only one case household as simple
case clusters. Similarly, suspect case clusters were formed and
differentiated as simple suspect clusters or composite suspect clusters.
Further, to serve as a control group, non-case clusters were constituted
from a systematic sample of 10% households that were not included
in case or suspect case clusters.
Out of 60 case clusters formed, only 7 have multiple
cases showing that there was no evidence of high concentration of
disease in case clusters. While the percentage of child contacts
(0-14 years) infected was considerably higher in case clusters (25.8%),
there was not much difference between suspect case clusters (14.9%)
and non-case clusters (9.8%). Similarly, there was not much difference
between simple and composite clusters. Infection among child contacts
was higher in case households as compared to their neighbourhoods.
To get some idea of the zone of influence of a case or suspect case,
prevalence of infection was studied for 10 neighbourhoods, in simple
clusters to avoid the influence of multiple cases. It appeared that
the zone of influence of a case may extend at least upto the 10th
neighbourhood. It was also noted that there was very little difference
between zones of influence of suspect cases and non-cases. Case
clusters in which the nucleus case had shown activity of lung lesion
(evident on X-ray reading) or had cough showed significantly higher
infection among child contacts. Clusters around cases positive on
both smear and culture did not show higher infection than those
around cases positive on culture only. (This may be due to sputum
examination of single specimen only).
Out of the total infected persons in the community,
only 2% were in case households and 7% in suspect case households,
over 90% being in non-case households. The zone of influence of
a case extending at least upto the 10th neighbourhood and the overlapping
of such zones of influence of cases, present and past, seems to
be the most probable explanation for the wide scatter of infection
in the community. Prevalence of infection among child contacts was
definitely higher in case clusters. But, the significance of this
could be understood only from a study of the incidence of disease
during subsequent years in different types of clusters. It is significant
that only 10% of the total infected persons in the community were
found in case clusters. The case yield in general population, cluster
contacts, household contacts and symptomatics attending general
health institutions have been also compared. The case yield in the
last group (10%) is much higher than the case yield from both types
of contacts (0.7% and 0.6%) which where only slightly higher than
the case yield from the general population (0.4%).
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KEYWORDS: RURAL, HOUSEHOLDS, CLUSTERS, CASE,
SUSPECT CASE, CONTACT, PREVALENCE, INFECTION, DISEASE, SURVEY. |
023 |
TUBERCULOSIS IN A RURAL POPULATION OF SOUTH INDIA:
A FIVE YEAR EPIDEMIOLOGICAL STUDY |
National Tuberculosis Institute, Bangalore: Bull
WHO 1974, 51, 473-88. |
A rural population of 65,000 belonging to 119 randomly
selected villages of Bangalore district was repeatedly examined
four times during 1961 to 1968, by tuberculin test, X-ray and sputum
examinations, to study the epidemiology of tuberculosis without
any active anti-tuberculosis measures. The interval between the
first and the fourth examination was 5 years. The coverage of various
examinations at different surveys were very high.
The main findings of the study are: Prevalence
rate of tuberculous infection in the population was about
30% (among females 25% and males 35%). The overall prevalence
rates of infection were fairly constant at all the four surveys,
but a steady decrease in the prevalence of infection was observed
in the age group 0-24 years. Annual incidence rate of infection
on the average was about 1%. During the study period,
the incidence of infection showed a decline from 1.63% to 0.8% for
all ages combined. Prevalence rate of disease ranged from
337 to 406 per 1,00,000 population during the study period,
the highest being at the time of first survey and lowest at the
time of third survey. For the younger age group of 5-34 years, the
rates showed continuous decrease during the study period. Annual
incidence rate of disease ranged from 79 to 132 per 1,00,000
population, highest being between first and second surveys and lowest
between second and third surveys. The incidence rate in younger
age groups below 35 years showed a decline during the study period.
Those with tuberculin test induration of 20mm or more had highest
annual incidence rate of disease. The annual incidence rate
of bacteriologically confirmed disease in the three radiological
groups of population was (i) 185 per 1,00,000 with normal X-rays,
(ii) 958 per 1,00,000 with abnormal shadows judged as inactive
tuberculous are non-tuberculous and (iii) 4,530 per 1,00,000 with
abnormal shadows judged as active or probably active tuberculous
but bacteriologically not confirmed. The third group constituted
1% of the total population and contributed 34% of the total incidence
cases. In each of the above three radiological groups, the incidence
of disease was highest among those with tuberculin test induration
of 20mm or more to 1 TU RT 23 with Tween 80. Those with 20mm or
more tuberculin test induration in the third radiological group
constituted 0.45% of the total population but contributed 27% of
the total incidence cases. Incidence rate for males was nearly double
that of females. More than half of the new male cases were 35 years
of age, whereas more than half the females were below the age of
35 years. Out of 126 cases followed up at three subsequent surveys
over a period of 5 years, 49.2% died, 32.5% got cured and 18.3%
continued to remain sputum positive. Both death and cure rates
were highest during the first one and a half year period.
About 30% of newly detected cases come from population
uninfected at an earlier survey. Both infection and disease showed
a decline in the younger age group. There was no evidence of an
increase in drug resistance among newly diagnosed cases. Incidence
of cases showed a higher natural cure. These findings indicate that
tuberculosis cases are not a uniform entity. There can be different
gradations from the point of view of diagnosis and ability to benefit
from treatment. The differences between male and female patients
with regard to death and cure rates support this view
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.KEY WORDS: TREND, RURAL POPULATION, PREVALENCE,
INCIDENCE, INFECTION, DISEASE, LONGITUDINAL SURVEY. |
028 |
FIVE YEAR INCIDENCE OF TUBERCULOSIS AND CRUDE MORTALITY
IN RELATION TO NON SPECIFIC TUBERCULIN SENSITIVITY |
GD Gothi, SS Nair, AK Chakraborty & KT Ganapathy:
Indian J TB 1976, 23, 58-63. |
The study was undertaken in a sample of 103 villages
of 3 sub-divisions of Bangalore district as a part of the 5 year
study of epidemiology of tuberculosis between 1961-68. The follow
ups were done at 1.5, 3 & 5 years after the first survey.
The entire population was offered tuberculin test with 1 TU RT 23,
a second test with 20 TU RT 23 to those persons who were having
reactions of 0-13 mm to 1 TU. All aged 5 years or more were offered
70mm photofluorograms at each survey. Two specimens of sputum were
collected from persons having abnormal X-ray shadows for examination
of tubercle bacilli. Procedures were uniform at each survey. The
population was divided into three groups on the basis of their tuberculin
reactions: (a) reactors to 1 TU (infected with M.tuberculosis),
b) non-reactors to 1 TU but reactors to 20 TU (infected with atypical
mycobacteria), c) non-reactors to both 1 TU & 20 TU (not infected
with either M.tuberculosis or other mycobacteria). Incidence of
disease and crude mortality were studied separately among these
groups.
The five year incidence of culture positive disease
was the highest among 1 TU reactors and the least among reactors
to 20 TU. In the younger age group (5-14 years) the five year incidence
of culture positive disease among reactors to 20 TU was significantly
lower compared with that among 20 TU non-reactors. The reduction
of incidence of culture positive cases in the former group over
that in the latter was 75% for culture positive cases and 61% for
combined culture positive and negative disease. As regards crude
mortality, the overall rate was significantly lower among 20 TU
reactors compared with non-reactors. Even if the significance of
the finding on crude mortality is debatable, it could be concluded
that non-specific infection provides some protection against development
of tuberculosis, at least in younger age groups.
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KEY WORDS: INCIDENCE, DISEASE, MORTALITY, NTM,
RURAL POPULATION. |
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