|ENHANCING OF TUBERCULIN ALLERGY BY PREVIOUS TUBERCULIN
|Raj Narain, SS Nair, G Ramanatha Rao, P Chandrasekhar
& Pyare Lal: Indian J TB 1966, 13, 43-56; Tables i-vii.
Tuberculin tests repeated after an interval of
time, at a different site have been reported to elicit reactions
larger than the first test. A study was undertaken where reactors
of 13mm or less to 1 TU have been tested with 20TU for the study
of low grade reactions. Study was carried out in a previously untested
and unvaccinated rural population (Longitudinal Survey), where only
about 25% of the population showed 14mm or more to 1 TU and the
remaining about 60% showed 10mm or larger reactions to 20 TU. These
results confirm the high prevalence of non-specific allergy in the
It was found that a tuberculin test does enhance
the allergy elicited by a subsequent test. The enhancing effect
is associated with the initial allergy i,e., 8-13mm to 1 TU tuberculin,
especially those elicited by a 20 TU test, increase being almost
confined to those with 10mm and larger reactions to 20 TU. The enhancing
effect increases with increase in age especially among those with
10mm or bigger reactions to 20 TU. It is possible that the enhancing
effect is more in communities with high prevalence of non-specific
|KEY WORDS: TUBERCULIN REACTION, ENHANCEMENT,
NON SPECIFIC ALLERGY, INFECTION, M.TUBERCULOSIS, NTM.
|PREVALENCE OF NON-SPECIFIC SENSITIVITY TO TUBERCULIN
IN A SOUTH INDIAN RURAL POPULATION
|AK Chakraborty, KT Ganapathy, SS Nair & Kul Bhushan:
Indian J Med Res 1976, 64, 639-51.
The data from a tuberculosis prevalence survey
carried out in three taluks of Bangalore district in south India
during 1961-68 were analysed to study (i) the prevalence of non-specific
sensitivity in the community i.e., prevalence of infection with
mycobacteria other than M.tuberculosis, as found by testing the
population with tuberculin RT 23 of a lower strength (1 TU) and
higher strength (20 TU), both with Tween 80 and (ii) additional
boosting if any, resulting from testing with higher dose of tuberculin,
immediately following a test with 1 TU RT 23.
The level of demarcation between infected and uninfected
with 1 TU was 0-9 mm induration size and this negative group tested
with 20 TU dose induration of 8 mm or more was considered positive.
Prevalence of infection with M.tuberculosis in the community were
2.1% in 0-4 years, 7.9% in 5-9 years, 16.5% in 10-14 years, 33.2%
in 15-24 years and overall 14.5% in 0-24 years of age group. Infection
rate with other mycobacteria were 12.9%, 44.9%, 66.2%, 62.4% and
45.7% respectively in the above stated different age groups.
Testing the population with 20 TU RT 23 following
a 1 TU test was found not to boost the tuberculin reactions over
that observed on a single test with 1 TU only.
|KEY WORDS: NTM, PREVALENCE, INFECTION, BOOSTING,
TUBERCULIN REACTION, RURAL POPULATION.
|EFFECT OF NUTRITIONAL STATUS ON DELAYED HYPERSENSITIVITY
DUE TO TUBERCULIN TEST IN CHILDREN OF AN URBAN SLUM COMMUNITY
|AK Chakraborty, KT Ganapathy & R Rajalakshmi: Indian
J TB 1980, 27, 115-19.
Prevalence of tuberculous infection in young children
is an important surveillance measure. However, the hypersensitivity
may be depressed by malnutrition and thus interfere with the interpretation
of tuberculin test leading to underestimation of the infection rate.
Objective of this investigation was to study the relationship between
tuberculin reaction with 1 TU RT 23 and nutritional status of children.
The study was carried out in 1974 among children aged 1-9 years
of age living in an urban slum area of Bangalore city and who were
not given BCG vaccination.
Of the 1151 registered children aged 0-9 years,
482 in the age group 1-4 and 526 in 5-9 years formed the study group.
Of these 1008 children, 980 had both clinical evaluation and anthropometric
measurement for nutritional status and 963 had both tuberculin test
readings and anthropometric measurements carried out for them. Of
the 482 children aged 1-4 years, 230 were classified as suffering
from Protein Calorie Malnutrition (PCM) and of the 498 in the 5-9
years of age, 227 were classified as suffering from PCM. Distribution
of tuberculin test indurations in mm among the normals and the undernourished
were compared; no significant difference in the mean size of tuberculin
indurations as well as in the distributions of these indurations
was observed, regardless of the method used for arriving at the
|KEY WORDS: NUTRITIONAL STATUS, TUBERCULIN REACTION,
SLUM COMMUNITY, INFECTION.
|DOES MALNUTRITION AFFECT TUBERCULIN HYPERSENSITIVITY
REACTION IN THE COMMUNITY
|KT Ganapathy, AK Chakraborty: Indian J Pediatrics
1982, 49, 377-82
Distribution of tuberculin test indurations were
studied in relation to nutritional status of 930 rural children
aged 1-4 years and 796 aged 5-9 years. Using Quetlet's Index, it
has been observed that the distribution of indurations were similar
in normal and malnourished children. By following Jelliffe's criteria
of grading nutrition, no correlation was observed between the size
of induration and degree of malnutrition. It is concluded that malnutrition
in the community may not influence the prevalence rates of tuberculin
infection based on such testing.
|KEY WORDS: MALNUTRITION, TUBERCULIN REACTION,