Today, treatment of TB has developed into the concept of “case-holding” which involves the health agency, the patient, his/ her family and the community for the completion of treatment by the patient. The drug regimen plays a relatively minor role in case-holding when compared with other factors such as the active participation of the patient, family and close friends, the attitude and behaviour of the health staff who offer the treatment and, a constant supply of drugs and their availability to the patient. The services offering the treatment play a major role in reducing drug-default which is a primary problem in case-holding. The drug-default pattern in different situations is listed and the reasons for drug-default are discussed under three categories, technical, organizational and, administrative and socio-psychological.