||Gupta PR, Gupta ML, Purohit SD, Sharma TN & Bhatnagar
||Influence of prior information of drug toxicity on
||J ASSOC PHYSICIANS INDIA 1992, 40, 181-183.
The findings of the Fifth TB Association of Indias
SCC trial for the Jaipur Center were reanalysed. Sixty patients
with pulmonary TB, who had not received any chemotherapy in the
past, were divided into two groups. All the patients were put on
isoniazid, rifampicin and pyrazinamide for 8 weeks followed by isoniazid
and rifampicin for another 18 weeks. Group A patients were informed
of the likely occurrence of anorexia and /or vomiting but Group
B patients were not. Routine and default retrieval home visits were
given to ensure maximal drug compliance.
Drug toxicity-related early defaults were significantly
less common in Group A patients (1 of 30) as compared to group B
(6 of 30).
|KEYWORDS: MOTIVATION; COMPLIANCE; INDIA.