a) Treatment Failure & The Problem of Non Adherence
AU : Sophia Vijay, Balasangameshwara VH & Srikantaramu N
TI : Treatment dynamics and profile of tuberculosis patients under the District Tuberculosis Programme (DTP) – A prospective cohort study
SO : INDIAN J TB 1999, 46, 239-249
DT : Per
AB :

A prospective cohort study among new smear positive pulmonary TB cases initiated on SCC was undertaken in Kolar district of Karnataka. The objective was to study the treatment outcome and patient profile of treatment adherent (completed) and non-adherent (lost) patients. Data collection was done through interviews based on pre-tested structured schedules, soon after diagnosis and at the end of treatment. Of the 224 available patients in the cohort, 120 (53.6%) completed treatment, 68 (30.4%) were lost, 29 (12.9%) died and 7 (3.1%) migrated outside the district.

Persistence of cough at the end of treatment was significantly more among lost patients. The general profile of the patients, relating to socio-economic, demographic, literacy and employment details did not differ significantly between the 2 subgroups. However, the treatment related factors like distance from health centre, knowledge of treatment duration, advice on treatment given after diagnosis, payments made to staff and for tonics were significantly more among patients lost to treatment. Raising of money to meet the expenditure, particularly through selling of valuables too was proportionately more among lost patients. Defaulter retrieval action was not taken for more than 85% of all eligibles, both among completed and lost groups. The reasons for non-adherence to treatment as emerged from the study are mainly related to the treatment organization.

The study results emphasize the need to strengthen the treatment organization to achieve the desired treatment outcome. This would also be essential for a successful implementation of DOTS strategy.


  b) Measures to Improve Treatment Adherence  
AU : Jagota P, Balasangameshwara VH, Jayalakshmi MJ & Islam MM
TI : An alternative method of providing supervised Short Course Chemotherapy in District Tuberculosis Programme
SO : Indian J TB 1997, 44, 73-77
DT : Per
AB :

The feasibility of involving ‘Dai’s’ in supervised administration of an oral 6-month SCC regimen in DTP was studied in 2 districts. A concurrent comparison was made between the Dai Method and the present DTP procedure, called the PHI Method, in terms of treatment completion and cure rates at the end of treatment period. A total of 617 patients were observed; 332 in Dai method and 285 in PHI method. About 68% of patients in the Dai method and 33% in the PHI method took more than 75% of treatment in both intensive and continuation phases. The outcome in terms of smear negativity at the end of treatment period was 86.9% and 72.2% respectively. There were 17 (5.72%) deaths in the Dai method and 16 (8.5%) in the PHI method. Treatment completion and cure rates were significantly higher in the Dai method. It is concluded that Dais can be used for supervised drug administration in DTP for increasing the cure rates.


Patient Education at Door Steps