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026
INCIDENCE OF TUBERCULOSIS AMONG NEWLY INFECTED POPULATION AND IN RELATION TO THE DURATION OF INFECTED STATUS
VV Krishnamurthy, SS Nair, GD Gothi & AK Chakraborty: Indian J TB 1976, 23, 3-7.

Some of the parameters relating to duration of infected status and incidence of disease have been measured by analysing the data collected from the five year study. Between 1961-68, 119 villages in Bangalore district with total average population of about 62,000 were surveyed at intervals of 1, 3 and 5 years from the first survey. All persons were tuberculin tested with 1 TU RT 23 and those aged 5 years or more were X-rayed. Sputum of those persons showing any X-ray abnormality were collected and examined for AFB. Persons with X-ray abnormality but bacteriologically negative or with normal X-ray in all the preceding surveys, and who became culture positive with X-ray abnormality in the current survey were termed as "New cases". New cases who had shown 10 mm or more reaction to 1 TU RT 23 at I Survey were considered infected previously. New cases, tuberculin negative at I survey but who showed an increase of 16 mm or more between two consecutive surveys were considered infected midway between the two surveys.

Of the 42 new cases diagnosed from among the newly infected during 5 years, 81% came from those infected within one year. Incidence rate of cases among those who were infected within one year was about 5 times more than those infected earlier than one year. Incidence of cases steadily decreased with the increase in the duration of infection. Further, it was found that one fourth of all newly diagnosed cases came from the newly infected persons. However, the size of the pool of previously infected persons in a community being much larger, at least 72% of the new cases came from the reservoir of previously infected persons. The incidence of disease among the newly infected was almost the same in the three age groups i.e., 5-14, 15-34 and 35 years or more. But, the ratio of the incidence rates for the newly infected and the previously infected decreased from 13 for the age group 5-14 to 3 for the age group 35 years and above. In other words, the incidence of disease among the newly infected in the age group 5-14 was thirteen times more than for the previously infected in the same age-group whereas in the age-group 35 years and above, the incidence among newly infected was only thrice that among the previously infected.
Out of the 160 new cases diagnosed during the three repeat surveys, 21 per cent cases came from among those who were infected on the average for one year or less. This is almost in conformity with the hypothesis that one-fourth of all new active cases come from new infections less than a year old.

KEY WORDS: INCIDENCE, INFECTION, CASE, TUBERCULIN STATUS.
 
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