A prospective study was carried out to assess the impact of extra motivational efforts on the duration of unbroken drug-continuity in a cohort of 150 randomly selected TB patients undergoing anti-TB unsupervised domiciliary treatment at S.R.N. Hospital, M.L.N. Medical College, Alahabad. The contribution of extra-motivational efforts along with that of some other socio-economic characteristics of the patients, was obtained by the use of multiple regression analysis. It revealed that if monthly additional efforts of extra-motivation are made, devoting 15-20 minutes only in terms of explaining to the patient about the necessity and importance of regular and complete treatment, the average duration of unbroken treatment of a group of patients can be increased by as much as two months, a substantial gain from both curative as well as preventive aspects of any TB control programme.